The history of American Botanicals can be traced back to Wilcox Natural Products, previously one of the main botanical sourcing companies specializing in wildcrafted botanicals since 1900. Over the years, the company grew from a small business into a globally recognized supplier of quality medicinal and botanical products. Wilcox was under the management of Allen Lockard from 1985 until 1994. In 1994, the company began operating as American Botanicals with Lockard as president.

American Botanicals expanded again in 2016 when it purchased Famarco, a company out of Virginia Beach, Virginia. The company, strategically located next to a port, has over 80 years of history importing spices and is the largest domestic importer and roaster of carob. The Virginia Beach factory is another of three American Botanicals locations, focusing mostly on importing, manufacturing, and blending of wholesale organic spices, botanicals and herbs.